Updated: Mar 14
Many Americans are now eligible for COVID-19 booster shots. Solid evidence supports robust immune response following the mix-and-match booster shots, therefore it can be a difficult task to determine which vaccine to get as a booster.
A preliminary study reported from Science News suggests that people who got J&J as their first vaccine dose developed much higher levels of antibodies if their second dose was an mRNA vaccine than if it was another jab of J&J – thus suggesting people who received the J&J vaccine should consider getting an mRNA booster.
For anyone who received an mRNA-based vaccine primarily, they can get a third mRNA dose as the booster or could consider adenovirus-based vaccines like J&J’s and AstraZeneca’s since the spectrum of coverage between these two categories of vaccines seem to be different.
While the mRNA vaccines give massive levels of neutralizing antibodies, keeping the coronavirus from infecting cells; the adenovirus-based vaccines like J&J’s and AstraZeneca’s seem to be better at revving up long-lasting protection from immune cells called T-cells. Thus getting an adenovirus-based booster like J&J’s among mRNA vaccine recipients could have clear advantages.