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Recurrent UTIs linked to gut microbiome, chronic inflammation

Urinary Tract Infections (UTIs) involve the infection of any part of the urinary system including kidneys, ureters, bladder, and urethra and are among the most frequent infections worldwide, mostly among adult women. It reoccurs so often that a quarter of women develop a second UTI within six months, and some unfortunate individuals get it more frequently necessitating the repeated antibiotics use. Despite being such a common issue with its huge contribution in developing antimicrobial resistance, there is not yet a clear understanding on why that happens.

Studies suggest that the primary treatment with antibiotics eliminates disease-causing bacteria from the bladder but not from the gut leaving the gate open for surviving bacteria to multiply again and reinfect. Unfortunately, more frequent use of antibiotics disrupts the helpful gut microbiome that are known to check on the harmful bacteria, leaving the harmful bacteria unleashed to get activated and cause the infection again.

While newer information about the microbiome is emerging every day, the best bet at this point would be to confirm the pathogen and its antibiotic susceptibility profile at the first infection using a quick and reliable diagnostic test like Acutis Reveal™ UTI minimizing the need for repeated use of antibiotics, in-turn minimizing the disturbances to the beneficial gut microbiome.

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